#5890 THE IMPACT OF CKD STATUS BEFORE KIDNEY TRANSPLANTION ON ALPHATORQUEVIRUS DNA LEVELS

Abstract Background and Aims Torque teno virus (TTV) is a non-pathogenic anellovirus whose replication kinetics reflects the overall state of immunosuppression. Although chronic kidney disease (CKD) induces well-stabilised dysfunction immune system, long-term use renal replacement therapies (RRT) itself could also modify response. Method We analyzed TTV DNA loads at baseline (in pre-transplant assessment), day 7 months 1, 3,6 12 after transplantation (KT). Recipients were categorized according to their RRT status: pre-emptive KT (pre-KT), hemodialysis (HD) peritoneal dialysis (PD). load was measured by real-time polymerase chain reaction. Results A total 221 CKD patients analyzed. The mean age 53.9 ± 15.7 years, 72.4% males, hypertension (85.1%) diabetes (30.1%) most common comorbidities. According TTR status, 159 (72.0%) on HD, 35 (15.8%) PD 27 (12.2%) received pre-KT. There no differences in comorbidities or between except for residual diuresis (P <0.01). HD had higher serum albumin levels than receiving pre-KT (4.4 0.5 vs. 4.1 0.6 3.9 0.4 g/dL, respectively, P exhibited (3.4 ±1.2 log10 copies/mL) (2.8 1.6 (2.4 2.1 copies/mL), although not statistically significant. lower time (18.4± 16.2 37.5± 53.6 months, respectively; = 0.038). during post-transplant follow-up patients, viral comparable across these three groups month transplantation. Time associated with 0.18). status incidence infection composite opportunistic and/or de novo malignancy. Conclusion be useful identifying recipients high risk immunosuppression-related complications. presented non-significant load, we did find modality prior dialysis.